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The new study builds off observations made in 2003 by German neuroanatomist Heiko Braak that showed people with Parkinson’s disease also had accumulations of the misfolded alpha-synuclein protein in the parts of the central nervous system that control the gut
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People expect to have side effects on these drugs, so they drop out at the first hint of being on placebo, those patients thought they were on a placebo, but they weren’t
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