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(8) The researchers also commented that introduction of the peptide appeared to have increased bone mineralization in the murine models subjected to a combination of Ipamorelin and catabolism-inducing agents, in contrast to the control group receiving only catabolism-inducing agents

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First, the effect is enzymatic and cumulative — you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose