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This review critically evaluates current and emerging therapeutic strategies, including locoregional treatments, systemic chemotherapy, and combination therapies, alongside innovative approaches such as oncolytic viral therapy, EV-based therapies, non-coding RNA (ncRNA) interventions, electric field therapy, and precision medicine advancements (Fig
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This phenomenon may be attributed to PPARγ activation inhibiting NF-κB and AP-1 activity, reducing proinflammatory cytokine secretion, and directly promoting M2 gene expressio (Liu S
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