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Key Takeaways The range is enormous: published elimination half-lives across peptide classes span from about 8 minutes (tesamorelin) to about a week (semaglutide) — a factor of roughly 1,200 Half-life is not duration of effect: CJC-1295 has a reported half-life of 5.8-8.1 days but raised IGF-1 for 9-11 days after a single dose in the original trial Half-life is not a detection window: those are different measurements answering different questions, and we do not publish the second Molecular design drives everything: albumin binding, acylation, and conjugation are what separate a 10-minute peptide from a 7-day one Most research peptides have no human data: for compounds like BPC-157 the published pharmacokinetics are animal studies, not human trials "How long do peptides stay in your system?" has no single answer, because "peptides" is not a pharmacological category in any useful sense

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