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Biomedical applications of AFM, which can operate in ambient air, high vacuum, and liquid environments, are centered at topographic imaging [e.g., it can resolve DNA double helix (Mou et al., 1995) or probe structure and dynamics of nucleosomes (Stumme-Diers et al., 2019), or visualize and provide topological information about amyloid fibrils (Aubrey et al., 2020
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