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Natural Factors MSM Methyl-Sulfonyl-Methane 1000mg Matraea Relaxing Massage Oil Q1: Can I use MadNatural Factors MSM Methyl Sulfonyl Methane 1000mg Capsules Methyl sulfonyl methane (MSM) relieves joint pain naturally by helping the body form healthy connective tissue in joints and muscles. It is also used to make the collagen needed for healthy skin, hair, and nails. Natural Factors MSM can help improve the comfort and mobility of people with osteoarthritis.* Benefits Antioxidant protection*. Improves the appearance of hair, skin and nails*.